Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida.

ABSTRACT: A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.

SUBMITTER: Stephens MD 

PROVIDER: S-EPMC5279706 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature