Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture.

ABSTRACT: Leishmania are unicellular eukaryotes responsible for leishmaniasis in humans. Like other trypanosomatids, leishmania regulate protein coding gene expression almost exclusively at the post-transcriptional level with the help of RNA binding proteins (RBPs). Due to the presence of polycystronic transcription units, leishmania do not regulate RNA polymerase II-dependent transcription initiation. Recent evidence suggests that the main control points in gene expression are mRNA degradation and translation. Protein-RNA interactions are involved in every aspect of RNA biology, such as mRNA splicing, polyadenylation, localization, degradation, and translation. A detailed picture of these interactions would likely prove to be highly informative in understanding leishmania biology and virulence. We

SUBMITTER: Nandan D 

PROVIDER: S-EPMC5279761 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature