Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing.

ABSTRACT: Microbial burden of chronic wounds is believed to play an important role in impaired healing and the development of infection-related complications. However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size. We systematically evaluated the temporal dynamics of the microbiota colonizing diabetic foot ulcers, a common and costly complication of diabetes, and its association with healing and clinical complications. Dirichlet multinomial mixture modeling, Markov chain analysis, and mixed-effect models were used to investigate shifts in the microbiota over time and their associations with healing. Here we show, to our knowledge, previously unreported temporal dynamics of the chroni

SUBMITTER: Loesche M 

PROVIDER: S-EPMC5279919 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature