The association of anti-platelet factor 4/heparin antibodies with early and delayed thromboembolism after cardiac surgery.

ABSTRACT: Essentials We evaluated antibody status, thromboembolism and survival after cardiac surgery. Positive antibody tests are common - over 50% are seropositive at 30 days. Seropositivity did not increase thromboembolism or impair survival after cardiac surgery. Results show heparin induced thrombocytopenia antibody screening after surgery is not warranted.

Summary

Background Heparin-induced thrombocytopenia (HIT) is a prothrombotic response to heparin therapy with platelet-activating, anti-platelet factor 4 (PF4)/heparin antibodies leading to thrombocytopenia associated with thromboembolism. Objective We tested the hypothesis that anti-PF4/heparin antibodies are associated with thromboembolism after cardiac surgery. Methods This multicenter, prospective cohort study collected laboratory

SUBMITTER: Welsby IJ 

PROVIDER: S-EPMC5280211 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature