Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames.

ABSTRACT: Three-dimensional mesoscale clusters that are formed from nanoparticles spatially arranged in pre-determined positions can be thought of as mesoscale analogues of molecules. These nanoparticle architectures could offer tailored properties due to collective effects, but developing a general platform for fabricating such clusters is a significant challenge. Here, we report a strategy for assembling three-dimensional nanoparticle clusters that uses a molecular frame designed with encoded vertices for particle placement. The frame is a DNA origami octahedron and can be used to fabricate clusters with various symmetries and particle compositions. Cryo-electron microscopy is used to uncover the structure of the DNA frame and to reveal that the nanoparticles are spatially coordinated in the presc

SUBMITTER: Tian Y 

PROVIDER: S-EPMC5282466 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature