SNP variants associated with non-Hodgkin lymphoma (NHL) correlate with human leukocyte antigen (HLA) class II expression.

ABSTRACT: Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271100, rs2647012 and rs10484561) regions in a total of 1,145 subjects (567 NHL cases and 578 healthy controls) from two major ethnic groups in Malaysia, the Malays and the Chinese. We identified a NHL-associated (P_{NHL_add} = 0.0008; OR_{NHL_add} = 0.54; 95% CI = 0.37-0.77) and B-cell associated (P_{Bcell_add} = 0.0007; OR_{Bcell_add} = 0.51; 95% CI = 0.35-0.76) SNP rs2647012 in the Malaysian Malays. In silico cis-eQTL analysis of rs2647012 sugge

SUBMITTER: Ten LC 

PROVIDER: S-EPMC5282517 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature