Ontology highlight
ABSTRACT:
SUBMITTER: Madelaine R
PROVIDER: S-EPMC5282529 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170131
RFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied the structural and functional connections from NPVF neurons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics, and calcium imaging in behaving larval zebrafish. We found a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN). We sho ...[more]