Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.

ABSTRACT: Monitoring of neuronal activity within circuits facilitates integrated responses and rapid changes in behavior. We have identified a system in Caenorhabditis elegans where neuropeptide expression is dependent on the ability of the BAG neurons to sense carbon dioxide. In C. elegans, CO₂ sensing is predominantly coordinated by the BAG-expressed receptor-type guanylate cyclase GCY-9. GCY-9 binding to CO₂ causes accumulation of cyclic GMP and opening of the cGMP-gated TAX-2/TAX-4 cation channels; provoking an integrated downstream cascade that enables C. elegans to avoid high CO₂. Here we show that cGMP regulation by GCY-9 and the PDE-1 phosphodiesterase controls BAG expression of a FMRFamide-related neuropeptide FLP-19 reporter (flp-19::GFP). This regulation i

SUBMITTER: Rojo Romanos T 

PROVIDER: S-EPMC5282578 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature