Hepatic steatosis and cardiovascular disease outcomes: An analysis of the Framingham Heart Study.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and is associated with development of metabolic disease including atherosclerotic cardiovascular disease (CVD). Our aim is to examine the association of hepatic steatosis with prevalent clinical and subclinical CVD outcomes in a large community-based sample, the Framingham Heart Study.

Methods

Hepatic steatosis was measured in 3529 participants using multidetector computed tomography scanning. Multivariable logistic regression was used to determine whether hepatic steatosis is associated with prevalent CVD adjusted for covariates. We also tested whether associations were independent of other metabolic diseases/traits. The primary clinical outcome was composite prevalent clinical CVD defined by pr

SUBMITTER: Mellinger JL 

PROVIDER: S-EPMC5282653 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature