Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from India.

ABSTRACT:

Background

Miltefosine unresponsive and relapse cases of visceral leishmaniasis (VL) are increasingly being reported. However, there has been no laboratory confirmed reports of miltefosine resistance in VL. Here, we report two laboratory confirmed cases of VL from India.

Methods

Two patients with VL were referred to us with suspected VL. The first patient was a native of the VL endemic state of Bihar, but residing in Delhi, a VL non-endemic area. He was treated with broad-spectrum antibiotics and antipyretics but was unresponsive to treatment. The second patient was from Jharkhand state in eastern India (adjoining Bihar), another endemic state for VL. He was refractory to anti-leishmanial treatment, which included administration of miltefosine. Following investigation, both

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC5282768 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature