Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.

ABSTRACT:

Background

The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bleeding trauma patients. However, the effect appeared to depend on how soon after injury TXA treatment was started. Treatment within 3 h reduced bleeding deaths whereas treatment after 3 h increased the risk. We examine how patient characteristics vary by time to treatment and explore whether any such variations explain the time-dependent treatment effect.

Methods

Exploratory analysis were carried out, including per-protocol analyses, of data from the CRASH-2 trial, a randomised placebo-controlled trial of the effect of TXA on mortality in 20,211 trauma patients with, or at risk of, significant bleeding. We examine how patient characteristics (age, type of injury, presence or

SUBMITTER: Roberts I 

PROVIDER: S-EPMC5282847 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature