The influence of placental metabolism on fatty acid transfer to the fetus.

ABSTRACT: The factors determining fatty acid transfer across the placenta are not fully understood. This study used a combined experimental and computational modeling approach to explore placental transfer of nonesterified fatty acids and identify the rate-determining processes. Isolated perfused human placenta was used to study the uptake and transfer of ¹³C-fatty acids and the release of endogenous fatty acids. Only 6.2 ± 0.8% of the maternal ¹³C-fatty acids taken up by the placenta was delivered to the fetal circulation. Of the unlabeled fatty acids released from endogenous lipid pools, 78 ± 5% was recovered in the maternal circulation and 22 ± 5% in the fetal circulation. Computational modeling indicated that fatty acid metabolism was necessary to explain the discrepancy be

SUBMITTER: Perazzolo S 

PROVIDER: S-EPMC5282960 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature