The epichaperome is an integrated chaperome network that facilitates tumour survival.

ABSTRACT: Transient, multi-protein complexes are important facilitators of cellular functions. This includes the chaperome, an abundant protein family comprising chaperones, co-chaperones, adaptors, and folding enzymes-dynamic complexes of which regulate cellular homeostasis together with the protein degradation machinery. Numerous studies have addressed the role of chaperome members in isolation, yet little is known about their relationships regarding how they interact and function together in malignancy. As function is probably highly dependent on endogenous conditions found in native tumours, chaperomes have resisted investigation, mainly due to the limitations of methods needed to disrupt or engineer the cellular environment to facilitate analysis. Such limitations have led to a bottleneck in ou

SUBMITTER: Rodina A 

PROVIDER: S-EPMC5283383 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature