S100A8⁺ stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma.

ABSTRACT: Gene microarray and bioinformatic analysis showed that S100A8 was more abundant in the stroma surrounding tumor buddings (TBs) than in the stroma surrounding primary tumor cells in colorectal carcinomas. Here, S100A8⁺ cells in 419 colorectal carcinoma samples were stained by immunohistochemistry and counted using Image-pro plus 6.0. TBs were also counted and biomarkers associated with the epithelial-mesenchymal transition and apoptosis were assessed by immunohistochemistry. We evaluated the association between S100A8⁺ cells and clinico-pathological variables as well as survival. Migration and invasion as well as biomarkers of the epithelial-mesenchymal transition and apoptosis were tested in CRC cells, treated with graded concentrations of recombinant human S10

SUBMITTER: Li S 

PROVIDER: S-EPMC5283617 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature