Ontology highlight
ABSTRACT:
SUBMITTER: Coffey LL
PROVIDER: S-EPMC5283740 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
PloS one 20170131 1
Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias tha ...[more]