Encapsulation of Antifungals in Micelles Protects Candida albicans during Gall-Bladder Infection.

ABSTRACT: Candida albicans is a dimorphic fungus that colonizes human mucosal surfaces with the potential to cause life-threatening invasive candidiasis. Studies on systemic candidiasis in a murine infection model using in vivo real-time bioluminescence imaging revealed persistence of C. albicans in the gall bladder under antifungal therapy. Preliminary analyses showed that bile conferred resistance against a wide variety of antifungals enabling survival in this cryptic host niche. Here, bile and its components were studied for their ability to reduce antifungal efficacy in order to elucidate the underlying mechanism of protection. While unconjugated bile salts were toxic to C. albicans, taurine, or glycine conjugated bile salts were well tolerated and protective against

SUBMITTER: Hsieh SH 

PROVIDER: S-EPMC5285334 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature