3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer that affects ∼22 000 people in the United States yearly. Understanding the complex cellular interactions of the tumor microenvironment is critical to the success and development of DLBCL treatment strategies. In vitro platforms that successfully model the complex tumor microenvironment without introducing the variability of in vivo systems are vital for understanding these interactions. To date, no such in vitro model exists that can accurately recapitulate the interactions that occur between immune cells, cancer cells, and endothelial cells in the tumor microenvironment of DLBCL. To that end, we developed a lymphoma-on-chip model consisting of a hydrogel based tumor model traversed by a vascularized, perfusable, round microchan

SUBMITTER: Mannino RG 

PROVIDER: S-EPMC5285444 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature