Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.

ABSTRACT:

Objective

Genomewide association studies (GWAS) have identified consistent associations with obesity, with a number of studies implicating eating behavior as a primary mechanism. Few studies have replicated genetic associations with dietary intake. This study evaluates the association between obesity susceptibility loci and dietary intake.

Methods

Data were obtained as part of the Diabetes Prevention Program (DPP), a clinical trial of diabetes prevention in persons at high risk of diabetes. The association of 31 genomewide association studies identified obesity risk alleles with dietary intake, measured through a food frequency questionnaire, was investigated in 3,180 participants from DPP at baseline.

Results

The minor allele at BDNF, identified as protective against

SUBMITTER: McCaffery JM 

PROVIDER: S-EPMC5285480 | biostudies-literature | 2017 Feb/Mar

REPOSITORIES: biostudies-literature