The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism.

ABSTRACT: People with autism spectrum disorder and other neurodevelopmental disorders (NDDs) are behaviorally and medically heterogeneous. The combination of polygenicity and gene pleiotropy-the influence of one gene on distinct phenotypes-raises questions of how specific genes and their protein products interact to contribute to NDDs. A preponderance of evidence supports developmental and pathophysiological roles for the MET receptor tyrosine kinase, a multifunctional receptor that mediates distinct biological responses depending upon cell context. MET influences neuron architecture and synapse maturation in the forebrain and regulates homeostasis in gastrointestinal and immune systems, both commonly disrupted in NDDs. Peak expression of synapse-enriched MET is conserved across rodent and primate f

SUBMITTER: Eagleson KL 

PROVIDER: S-EPMC5285483 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature