Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.

ABSTRACT: Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic diversity and evolution. We analyse the effects of SVs on gene expression, quantitative traits and intrinsic reproductive isolation in the yeast Schizosaccharomyces pombe. We establish a high-quality curated catalogue of SVs in the genomes of a worldwide library of S. pombe strains, including duplications, deletions, inversions and translocations. We show that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover. These transient CNVs produce stoichiometric effects on gene expression both within and outside the duplicated regions. CNVs make substantial contributions to quantitative traits, most

SUBMITTER: Jeffares DC 

PROVIDER: S-EPMC5286201 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature