Succinate ester derivative of δ-tocopherol enhances the protective effects against ⁶⁰Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice.

ABSTRACT: α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total body irradiation (TBI). Because α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total body irradiation (TBI), we hypothesized succinate may be contribute to the radioprotection of α-TOS. To study the contributions of succinate and to identify stronger radioprotective agents, we synthesized α-, γ- and δ-TOS. Then, we evaluated their radioprotective effects and researched further mechanism of δ-TOS on hematological recovery post-irradiation. Our results demonstrated that the chemical g

SUBMITTER: Li ZT 

PROVIDER: S-EPMC5286428 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature