Gut metagenomes of type 2 diabetic patients have characteristic single-nucleotide polymorphism distribution in Bacteroides coprocola.

ABSTRACT:

Background

Gut microbes play a critical role in human health and disease, and researchers have begun to characterize their genomes, the so-called gut metagenome. Thus far, metagenomics studies have focused on genus- or species-level composition and microbial gene sets, while strain-level composition and single-nucleotide polymorphism (SNP) have been overlooked. The gut metagenomes of type 2 diabetes (T2D) patients have been found to be enriched with butyrate-producing bacteria and sulfate reduction functions. However, it is not known whether the gut metagenomes of T2D patients have characteristic strain patterns or SNP distributions.

Findings

We downloaded public gut metagenome datasets from 170 T2D patients and 174 healthy controls and performed a systematic comparative ana

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5286682 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature