The immunological response to syphilis differs by HIV status; a prospective observational cohort study.

ABSTRACT:

Background

It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals.

Methods

We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy.

Results

A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. At the baseline visit, compared to the control group, concentrations of IL-10 were significantly elevated in the HIV-infected and uninfected gr

SUBMITTER: Kenyon C 

PROVIDER: S-EPMC5286814 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature