The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells.

ABSTRACT:

Background

Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 to 70% in first-line therapy of advanced urothelial carcinoma. In the majority of cases, however, the duration of these responses is limited, and when progression occurs, the outcome is generally poor. Therefore, novel therapeutic strategies are urgently needed. The purpose of the current research is to investigate the anticancer effects and the mode of action of the marine triterpene glycoside frondoside A in p53-wild type and p53-deficient human urothelial carcinoma cells.

Methods

Activity of frondoside A was examined in the human urothelial carcinoma cell lines RT112, RT4, HT-1197, T

SUBMITTER: Dyshlovoy SA 

PROVIDER: S-EPMC5286817 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature