Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica.

ABSTRACT:

Background

Fasciola gigantica, the tropical liver fluke, infects buffaloes in Asian and African countries and causes significant economic losses and poses public health threat in these countries. However, little is known of the transcriptional response of buffaloes to infection with F. gigantica. The objective of the present study was to perform the first transcriptomic analysis of buffalo liver infected by F. gigantica. Understanding the mechanisms that underpin F. gigantica infection in buffaloes will contribute to our ability to control this parasite.

Methods

We challenged buffaloes with 500 viable F. gigantica metacercariae and collected liver samples through a time course at 3, 42 and 70 days post-infection (dpi). Then, we performed gene expression analysis on liver sam

SUBMITTER: Zhang FK 

PROVIDER: S-EPMC5286860 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature