MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion.

ABSTRACT: The control of genomic maintenance during S phase is crucial in eukaryotes. It involves the establishment of sister chromatid cohesion, ensuring faithful chromosome segregation, as well as proper DNA replication and repair to preserve genetic information. In animals, nuclear periphery proteins - including inner nuclear membrane proteins and nuclear pore-associated components - are key factors which regulate DNA integrity. Corresponding functional homologues are not so well known in plants which may have developed specific mechanisms due to their sessile life. We have already characterized the Gamma-tubulin Complex Protein 3-interacting proteins (GIPs) as essential regulators of centromeric cohesion at the nuclear periphery. GIPs were also shown to interact with TSA1, first described as a p

SUBMITTER: Batzenschlager M 

PROVIDER: S-EPMC5287105 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature