Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases.

ABSTRACT:

Importance

The causes of cognitive impairment in dementia with Lewy bodies (DLB) and Parkinson disease (PD) are multifactorial. Tau pathologic changes are commonly observed at autopsy in individuals with DLB and PD dementia, but their contribution to these diseases during life is unknown.

Objective

To contrast tau aggregation in DLB, cognitively impaired persons with PD (PD-impaired), cognitively normal individuals with PD (PD-normal), and healthy persons serving as control participants, and to evaluate the association between tau aggregation, amyloid deposition, and cognitive function.

Design, setting, and participants

This cross-sectional study was conducted from January 1, 2014, to April 28, 2016, in a tertiary care center's memory and movement disorders units. Twe

SUBMITTER: Gomperts SN 

PROVIDER: S-EPMC5287290 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature