Characterization of ADME gene variation in 21 populations by exome sequencing.

ABSTRACT:

Objective

Proteins involving absorption, distribution, metabolism, and excretion (ADME) play a critical role in drug pharmacokinetics. The type and frequency of genetic variation in the ADME genes differ among populations. The aim of this study was to systematically investigate common and rare ADME coding variation in diverse ethnic populations by exome sequencing.

Materials and methods

Data derived from commercial exome capture arrays and next-generation sequencing were used to characterize coding variation in 298 ADME genes in 251 Northeast Asians and 1181 individuals from the 1000 Genomes Project.

Results

Approximately 75% of the ADME coding sequence was captured at high quality across the joint samples harboring more than 8000 variants, with 49% of individuals car

SUBMITTER: Hovelson DH 

PROVIDER: S-EPMC5287433 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature