Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[M^I(CO)₃]⁺ (M = Re, ^99mTc) complexes.

ABSTRACT: In the last two decades, a number of chelate strategies have been proposed for the fac-[M^I(CO)₃]⁺ (M = Re, ^99mTc) core in radiopharmaceutical applications. However, the development of new ligands/complexes with improved function and in vivo performance has been limited in recent years. Expanding on our previous studies using the 2 + 1 labeling strategy, a series of bidentate ligands (neutral vs. anionic) containing an aromatic amine in combination with monodentate pyridine analogs or imidazole were explored to determine the influence of the bidentate and monodentate ligands on the formation and stability of the respective complexes. The 2 + 1 complexes with Re and ^99mTc were synthesized in two steps and characterized by standard radio/

SUBMITTER: Hayes TR 

PROVIDER: S-EPMC5287570 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature