Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.

ABSTRACT:

Background

Therapeutic targeting of arterial leukocyte recruitment in the context of atherosclerosis has been disappointing in clinical studies. Reasons for such failures include the lack of knowledge of arterial-specific recruitment patterns. Here we establish the importance of the cathepsin G (CatG) in the context of arterial myeloid cell recruitment.

Methods

Intravital microscopy of the carotid artery, the jugular vein, and cremasteric arterioles and venules in Apoe^-/-and CatG-deficient mice (Apoe^-/-Ctsg^-/-) was used to study site-specific myeloid cell behavior after high-fat diet feeding or tumor necrosis factor stimulation. Atherosclerosis development was assessed in aortic root sections after 4 weeks of high-fat diet, whereas lung infla

SUBMITTER: Ortega-Gomez A 

PROVIDER: S-EPMC5288007 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature