Activation of activator protein 2 alpha by aspirin alleviates atherosclerotic plaque growth and instability in vivo.

ABSTRACT:

Aims

Aspirin has been used for the secondary prevention and treatment of cardiovascular disease for several decades. We investigated the roles of transcriptional factor activator protein 2α (AP-2α) in the beneficial effects of aspirin in the growth and vulnerability of atherosclerotic plaque.

Methods and results

In mice deficient of apolipoprotein E (Apoe-/-), aspirin (20, 50 mg/kg/day) suppressed the progression of atherosclerosis in aortic roots and increased the plaque stability in carotid atherosclerotic plaques induced by collar-placement. In vivo lentivirus-mediated RNA interference of AP-2α reversed the inhibitory effects of aspirin on atherosclerosis in Apoe-/- mice. Mechanically, aspirin increased AP-2α phosphorylation and its activity, upregulated IkBα mRNA and pro

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC5288144 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature