Ontology highlight
ABSTRACT:
SUBMITTER: Kim RK
PROVIDER: S-EPMC5288197 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kim Rae-Kwon RK Kaushik Neha N Suh Yongjoon Y Yoo Ki-Chun KC Cui Yan-Hong YH Kim Min-Jung MJ Lee Hae-June HJ Kim In-Gyu IG Lee Su-Jae SJ
Oncotarget 20160801 33
Epithelial to mesenchymal transition (EMT) is developmental process associated with cancer metastasis. Here, we found that breast carcinoma cells adopt epithelial-to-mesenchymal transition (EMT) in response to fractionated-radiation. Importantly, we show that Notch signaling is highly activated in fractionally-irradiated tumors as compared to non-irradiated tumors that are accompanied by an EMT. Moreover, we uncovered the mechanism of Notch-driven EMT, in which Notch enhanced EMT through IL-6/JA ...[more]