Case-control study of candidate gene methylation and adenomatous polyp formation.

ABSTRACT:

Purpose

Colorectal cancer (CRC) is one of the most common and preventable forms of cancer but remains the second leading cause of cancer-related death. Colorectal adenomas are precursor lesions that develop in 70-90 % of CRC cases. Identification of peripheral biomarkers for adenomas would help to enhance screening efforts. This exploratory study examined the methylation status of 20 candidate markers in peripheral blood leukocytes and their association with adenoma formation.

Methods

Patients recruited from a local endoscopy clinic provided informed consent and completed an interview to ascertain demographic, lifestyle, and adenoma risk factors. Cases were individuals with a histopathologically confirmed adenoma, and controls included patients with a normal colonoscopy or t

SUBMITTER: Alexander M 

PROVIDER: S-EPMC5288296 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature