Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression.

ABSTRACT: Previously, we reported that B-cell chronic lymphocytic leukemia (CLL) patients contained elevated levels of microvesicles (MVs). However, given the quiescent nature of CLL B-cells and the relative indolence of the disease, the dynamics of MV generation and their unique phenotypes are not clearly defined. In this study, we find that CLL B-cells generate MVs spontaneously and can be further induced by B-cell receptor-ligation. Most interestingly, CLL B-cells predominantly generate CD52⁺ MVs, but not CD19⁺ MVs in vitro, suggesting preferential usage of CD52 into leukemic-MVs and that the CLL plasma MV phenotypes corroborate well with the in vitro findings. Importantly, we detected increased accumulation of CD52⁺ MVs in previously untreated CLL patients with p

SUBMITTER: Boysen J 

PROVIDER: S-EPMC5288303 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature