Comparative effectiveness of primary tumor resection in patients with stage IV colon cancer.

ABSTRACT:

Background

Although the safety of combination chemotherapy without primary tumor resection (PTR) in patients with stage IV colon cancer has been established, questions remain regarding a potential survival benefit with PTR. The objective of this study was to compare mortality rates in patients who had colon cancer with unresectable metastases who did and did not undergo PTR.

Methods

An observational cohort study was conducted among patients with unresectable metastatic colon cancer identified from the National Cancer Data Base (2003-2005). Multivariate Cox regression analyses with and without propensity score weighting (PSW) were performed to compare survival outcomes. Instrumental variable analysis, using the annual hospital-level PTR rate as the instrument, was used to acc

SUBMITTER: Alawadi Z 

PROVIDER: S-EPMC5288308 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature