Cortical excitability correlates with seizure control and epilepsy duration in chronic epilepsy.

ABSTRACT:

Objective

Cortical excitability differs between treatment responders and nonresponders in new-onset epilepsy. Moreover, during the first 3 years of epilepsy, cortical excitability becomes more abnormal in nonresponders but normalizes in responders. Here, we study chronic active epilepsy, to examine whether cortical excitability continues to evolve over time, in association with epilepsy duration and treatment response.

Methods

We studied 28 normal subjects, 28 patients with moderately controlled epilepsy (≤4 seizures per year) and 40 patients with poorly controlled epilepsy (≥20 or more seizures per year). Resting motor threshold (RMT), active motor threshold (AMT), short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and cortical silent period (C

SUBMITTER: Pawley AD 

PROVIDER: S-EPMC5288462 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature