Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice.

ABSTRACT: Fructose stimulates vasopressin in humans and can be generated endogenously by activation of the polyol pathway with hyperosmolarity. We hypothesized that fructose metabolism in the hypothalamus might partly control vasopressin responses after acute dehydration. Wild-type and fructokinase-knockout mice were deprived of water for 24 h. The supraoptic nucleus was evaluated for vasopressin and markers of the aldose reductase-fructokinase pathway. The posterior pituitary vasopressin and serum copeptin levels were examined. Hypothalamic explants were evaluated for vasopressin secretion in response to exogenous fructose. Water restriction increased serum and urine osmolality and serum copeptin in both groups of mice, although the increase in copeptin in wild-type mice was larger than that in fru

SUBMITTER: Song 宋志林 Z 

PROVIDER: S-EPMC5288484 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature