A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.

ABSTRACT: Short-term and long-term transcriptional memory is the phenomenon whereby the kinetics or magnitude of gene induction is enhanced following a prior induction period. Short-term memory persists within one cell generation or in postmitotic cells, while long-term memory can survive multiple rounds of cell division. We have developed a tissue culture model to study the epigenetic basis for long-term transcriptional memory (LTTM) and subsequently used this model to better understand the epigenetic mechanisms that enable heritable memory of temporary stimuli. We find that a pulse of transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) induces LTTM on a subset of target genes that survives nine cell divisions. The chromatin landscape at genes that acquire LTTM is more repressed than

SUBMITTER: Iberg-Badeaux A 

PROVIDER: S-EPMC5288571 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature