Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling.

ABSTRACT: The bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the context of osteoblast differentiation. However, the intracellular signaling cascades that mediate the osteoblastogenic function of Bmp have not been fully elucidated. By profiling mRNA expression in the bone marrow mesenchymal progenitor cell line ST2, we discover that BMP2 induces not only genes commonly associated with ossification and mineralization but also genes important for general protein synthesis. We define the two groups of genes as mineralization related versus protein anabolism signatures of osteoblasts. Although it induces the expression of several Wnt genes, BMP2 activates the osteogenic program largely independently of de novo Wnt secretion. Remarkably, although Smad4 is ne

SUBMITTER: Karner CM 

PROVIDER: S-EPMC5288572 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature