Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps.

ABSTRACT:

Objective

Whereas few adenomas become cancer, most colorectal cancers arise from adenomas. Telomere length is a recognized biomarker in multiple cancers, and telomere maintenance mechanisms (TMM) are exploited by malignant cells. We sought to determine whether telomere length and TMM distinguish cancer-associated adenomas from those that are cancer-free.

Methods

Tissues were identified as cancer-adjacent polyp (CAP)-residual adenoma contiguous with cancer-and cancer-free polyp (CFP)-adenomas without malignancy. Telomere length, TMM, and expression were measured in 102 tissues including peripheral blood leukocytes (PBLs), normal colon epithelium, adenoma, and cancer (in CAP cases) from 31 patients. Telomere length was measured in a separate cohort of 342 PBL from CAP and CFP

SUBMITTER: Druliner BR 

PROVIDER: S-EPMC5288594 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature