Transcriptomic investigation of wound healing and regeneration in the cnidarian Calliactis polypus.

ABSTRACT: Wound healing and regeneration in cnidarian species, a group that forms the sister phylum to Bilateria, remains poorly characterised despite the ability of many cnidarians to rapidly repair injuries, regenerate lost structures, or re-form whole organisms from small populations of somatic cells. Here we present results from a fully replicated RNA-Seq experiment to identify genes that are differentially expressed in the sea anemone Calliactis polypus following catastrophic injury. We find that a large-scale transcriptomic response is established in C. polypus, comprising an abundance of genes involved in tissue patterning, energy dynamics, immunity, cellular communication, and extracellular matrix remodelling. We also identified a substantial proportion of uncharacterised genes that were dif

SUBMITTER: Stewart ZK 

PROVIDER: S-EPMC5288695 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature