2-Year Natural Decline of Cardiac Sympathetic Innervation in Idiopathic Parkinson Disease Studied with 11C-Hydroxyephedrine PET.

ABSTRACT: The objective of this study was to detect regional patterns of cardiac sympathetic denervation in idiopathic Parkinson disease (IPD) using ¹¹C-hydroxyephedrine (¹¹C-HED) PET and determine the denervation rate over 2 y.

Methods

We obtained 62 cardiac ¹¹C-HED PET scans in 39 patients (30 men and 9 women; mean age ± SD, 61.9 ± 5.9 y), including 23 patients with follow-up scans at 2 y. We derived ¹¹C-HED retention indices (RIs; mL of blood/min/mL of tissue) reflecting nerve density and integrity for 480 left ventricular (LV) sectors. We compared IPD patients with 33 healthy controls using z score analysis; RI values ≤ 2.5 SDs were considered abnormal. We expressed global and regional LV denervation as the percentage extent of z score severity

SUBMITTER: Wong KK 

PROVIDER: S-EPMC5288743 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature