Ontology highlight
ABSTRACT:
SUBMITTER: Shishido Y
PROVIDER: S-EPMC5288785 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20170202
SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry Sertoli cells are not functionally equivalent to XY Sertoli cells, it has remained unclear which specific functions are affected. To elucidate the functional difference, we compare ...[more]