The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis.

ABSTRACT:

Background

Migraine is a recurrent headache disease related to genetic variants. The brain-derived neurotrophic factor (BDNF) gene rs6265 (Val66Met) and rs2049046 polymorphism has been found to be associated with migraine. However, their roles in this disorder are not well established. Then we conduct this meta-analysis to address this issue.

Methods

PubMed, Web of Science and Cochrane databases were systematically searched to identify all relevant studies. Odds ratio (OR) with corresponding 95% confidence interval (CI) was used to estimate the strength of association between BDNF gene rs6265 and rs2049046 polymorphism and migraine.

Results

Four studies with 1598 cases and 1585 controls, fulfilling the inclusion criteria were included in our meta-analysis. Overall dat

SUBMITTER: Cai X 

PROVIDER: S-EPMC5289130 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature