Mortality Among Men with Advanced Prostate Cancer Excluded from the ProtecT Trial.

ABSTRACT:

Background

Early detection and treatment of asymptomatic men with advanced and high-risk prostate cancer (PCa) may improve survival rates.

Objective

To determine outcomes for men diagnosed with advanced PCa following prostate-specific antigen (PSA) testing who were excluded from the ProtecT randomised trial.

Design, setting, and participants

Mortality was compared for 492 men followed up for a median of 7.4 yr to a contemporaneous cohort of men from the UK Anglia Cancer Network (ACN) and with a matched subset from the ACN.

Outcome measurements and statistical analysis

PCa-specific and all-cause mortality were compared using Kaplan-Meier analysis and Cox's proportional hazards regression.

Results and limitations

Of the 492 men excluded from the ProtecT co

SUBMITTER: Johnston TJ 

PROVIDER: S-EPMC5289293 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature