From ORFeome to biology: a functional genomics pipeline.

ABSTRACT: As several model genomes have been sequenced, the elucidation of protein function is the next challenge toward the understanding of biological processes in health and disease. We have generated a human ORFeome resource and established a functional genomics and proteomics analysis pipeline to address the major topics in the post-genome-sequencing era: the identification of human genes and splice forms, and the determination of protein localization, activity, and interaction. Combined with the understanding of when and where gene products are expressed in normal and diseased conditions, we create information that is essential for understanding the interplay of genes and proteins in the complex biological network. We have implemented bioinformatics tools and databases that are suitable to sto

SUBMITTER: Wiemann S 

PROVIDER: S-EPMC528930 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature