Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice.

ABSTRACT: Women are at an increased risk for developing affective disorders during times of hormonal flux, including menopause when the ovaries cease production of estrogen. However, while all women undergo menopause, not all develop an affective disorder. Increased vulnerability can result from genetic predisposition, environmental factors and gene by environment interactions. In order to investigate interactions between genetic background and estrogen depletion, we performed bilateral ovariectomy, a surgical procedure that results in estrogen depletion and is thought to model the post-menopausal state, in a genetically defined panel of 37 inbred mouse strains. Seventeen days post-ovariectomy, we assessed behavior in two standard rodent assays of anxiety- and depressive-like behavior, the open fiel

SUBMITTER: Schoenrock SA 

PROVIDER: S-EPMC5289389 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature