Role of nanoparticle size, shape and surface chemistry in oral drug delivery.

ABSTRACT: Nanoparticles find intriguing applications in oral drug delivery since they present a large surface area for interactions with the gastrointestinal tract and can be modified in various ways to address the barriers associated with oral delivery. The size, shape and surface chemistry of nanoparticles can greatly impact cellular uptake and efficacy of the treatment. However, the interplay between particle size, shape and surface chemistry has not been well investigated especially for oral drug delivery. To this end, we prepared sphere-, rod- and disc-shaped nanoparticles and conjugated them with targeting ligands to study the influence of size, shape and surface chemistry on their uptake and transport across intestinal cells. A triple co-culture model of intestinal cells was utilized to more

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC5289391 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature