Ontology highlight
ABSTRACT:
SUBMITTER: Atianand MK
PROVIDER: S-EPMC5289747 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cell 20160601 7
Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, we identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely regulated in macrophages to control the expression of immune response genes (IRGs). Transcriptome analysis of macrophages from lincRNA-EPS-deficient mice, combined with gain-of-function and rescue experiments, revealed a specific role ...[more]