VEGF Promoter Polymorphism Confers an Increased Risk of Pulmonary Arterial Hypertension in a Chinese Population.

ABSTRACT:

Purpose

Evidence on the contribution of genes to the hereditary predisposition to pulmonary arterial hypertension (PAH) is limited.

Materials and methods

In this study, we hypothesized that single nucleotide variants in vascular endothelial growth factor (VEGF) gene may alter gene function and expression and may be associated with PAH risk. Five putatively functional loci (rs699947C>A and rs833061T>C in the promoter, rs3025040C>T, rs10434G>A and rs3025053G>A in the 3'-UTR) in the VEGF gene were genotyped and analyzed in a retrospective study of 587 patients with PAH and 736 healthy subjects from southern China.

Results

We found that the rs833061T>C polymorphism was significantly associated with PAH risk, while the other single nucleotide polymorphisms were not. Compar

SUBMITTER: Zhuo Y 

PROVIDER: S-EPMC5290009 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature